Course Details
Subject {L-T-P / C} : CY2102 : Organic Chemistry: Structure and Reactivity { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Niranjan Panda
Syllabus
Substitution Reactions at sp3 Carbons: Types (SN1, SN2, SNi), neighboring group participation, factors affecting SN reaction, Competition between SN1 and SN2 reactions, Substitution reactions of alcohols, alkyl halides, reactions with epoxides.
Addition Reactions at sp2 Carbons: Addition of Carbon, Hydrogen, oxygen, sulfur and Nitrogen nucleophiles to Carbonyl Compounds, Wittig reaction, Schiff’s base-hydrazone, oxime, Cannizzaro's reaction, acetal Synthesis, a,ß-unsaturated carbonyl compounds-preparation and properties, Michael addition, 1,2 Vs 1,4- addition reaction.
Acidity of a-hydrogen: Keto-enol tautomerism, alkylation, acylation, halogenation, Aldol condensation, Robbinson annulation, Perkin’s reaction, Claisen condensation, Dieckmann condensation Reaction, Stobbe Condensation Reaction, Morita's-Baylis-Hilmann reaction, Bamford-Steven, Shapiro reaction, base-catalyzed halogenations reaction of ketones (Iododform reaction,), active methylene compounds and their reactions, Malonic ester, acetoacetic ester.
Carboxylic acid and its derivatives (esters, anhydrides, acid halides, amides): Relative Reactivities, Nucleophilic acyl substitution reactions, Synthesis and reactions.
Course Objectives
- To build a clear understanding of how differently hybridized carbon atoms undergo reaction
- Stereochemical output of the reaction
Course Outcomes
1) Aims to provide a basic concept on stereochemistry. <br />2) Students will be able to transit from memorization to understanding by programmed exposure to integrated problems involving mechanism and multi-step synthetic planning. <br />3) It will provide a rational transition from studying simple organic compounds to complex ones.
Essential Reading
- P.Y. Bruice, Organic Chemistry, Pearson Education , 3rd Ed. 2009
- T. W. Graham Solomons, Craig B. Fryhle, Scott A. Snyder, Organic Chemistry, Wiley student Edition , 12th Ed. 2016
Supplementary Reading
- T. L. Gilchrist, Heterocyclic Chemistry, Pearson Education , 3rd Ed. 2007
- J. Clayden, N. Greeves, and S. warren, Organic Chemistry: Second Edition, oxford press , 2014