Course Details
Subject {L-T-P / C} : LS5106 : Structural Biology { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Samir Kumar Patra
Syllabus
The concept of Structural Biology, Evolutionary relationships of structural features of proteins. Determinants of protein structure and current views of protein folding. Motions in macromolecules and the functional importance of dynamics, the basis for various types of macromolecular interactions including protein- protein and protein-nucleic acid interactions, the chemical basis for interactions with enzyme inhibitors and other ligands. X-ray crystallographic and NMR-structure of proteins and nucleic acids. The proposition of DNA double helical structure in understanding the blueprint of life, Watson and Crick model. Fine structure of fibrous, globular and membrane proteins, Nucleosome and Chromatin structure. Cytoskeleton structure and protein-protein network
Course Objectives
- Structure and Function relationship
- Essentials of protein folding and enzyme function
- Dynamics of macromolecular assemblages in life proceses
Course Outcomes
• Students should be familiar with the NMR, X-ray and computational techniques used to study macromolecular structure. <br />• Students will understand the basics of various types of macromolecular interactions.
Essential Reading
- Lilgas A, Lilgas L, JuiPiskur et al., Textbook of Structural Biology (2009)., World Scientific Publishing, Singapore.
- Rice PA (Ed.), Protein-nucleic acid interactions: structural biology, 2008, Royal Society of Chemistry, Cambridge , ISBN-9780854042722
Supplementary Reading
- Grisshammer R (Ed.), Structural Biology of Membrane Proteins, 2006, Royal Society of Chemistry, Cambridge , ISBN-9780854043613
- Kobe Bostjan (Ed.), Structural proteomics: high-throughput methods, 2008, Humana Press, New Jersey , ISBN-9781588298096
Journal and Conferences
- J Struct Biol
- Nature, Science, cell