Course Details
Subject {L-T-P / C} : LS5105 : Chromatin Dynamics and Gene Regulations { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Samir Kumar Patra
Syllabus
Genome architecture, gene function, Chromatin organisation and gene expression, Stem cells, Reprogramming and Regeneration, Epigenetics, DNA methylation, histone modifications Regulation of gene expression in eukaryotes, Structural genomics, alteration in gene regulation and diseases, Modulation of chromatin dynamics
Course Objectives
- Gene, genetic and epigenetic basis of life
- Molecular understanding of development
- Molecular basis of differentiation
- Understanding the differences between normal and pathophysiology
Course Outcomes
• Students will be able to explain about chromatin structure and gene regulation in detail <br />• Students will be able to describe the concept of epigenetics and its effect
Essential Reading
- Allis C David (Ed.), Epigenetics, 2007, Cold Spring Harbor, New York , ISBN-978087969875
- Naumova Anna K (Ed.), Epigenetics and Complex Traits, 2013, Springer, New York , ISBN-9781461480778
Supplementary Reading
- Bidlack Wayne R (Ed.), Nutritional Genomics: the impact of dietary regulation of gene function on human, 2012, CRC Press, Boca Raton, , ISBN-9781439844526
- Bina Minou (Ed.), Gene regulation: methods and protocols, 2013, Springer, New York , ISBN-9781627032834
Journal and Conferences
- Cell, Nature, Science, Annual Rev of Biochemistry, Cell Biology
- Epigenetics, FEBS J, BBA, Clinical Epigenetics