Course Details
Subject {L-T-P / C} : CY5103 : Heterocycles and Natural Products { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof.(Ms.) Sabita Patel
Syllabus
Heterocycles: Nomenclature of Heterocycles with more than one heteroatom, Structure and uses of
heterocyclic compounds, Synthesis and Reactivity of indoles, azines, purines, pyrimidines, pteridines,
azeridine, oxirane, thiirane, oxaziridine, azetidine, azetidinone, oxetane, oxetanone, thietane,
azoles,fused heterocycles containing oxygen and sulfur hetero atoms (benzofurans,
benzothiophene, benzopyrones). Heterocycles in natural products, medicines and
materials.Alkaloids: Occurrence, Functions of Alkaloids, Classification, Isolation, Properties, and
synthesis: Quinine (Coniine), Morphine. Terpenoids: Classification, Structural features of Terpenoids,
specific importance to reactions of double bonds with Chromic acid, Ozone, catalytic hydrogenation,
Tilden reagent, Hydroxylating agents etc. Monoterpenoids, diterpenoids, Triterpenoids.Detailed
discussions on Menthol.Geometrical considerations of Neral& Geranial, Menthol.Biosynthesis of
natural products. Steroids: General biosynthesis studies of steroids, structure of cholesterol and
ergosterol (synthesis). Stereochemistry of steroids, chemistry of bile acids.Hormones: Definition,
classification, synthesis of adrenaline, thyroxine, Structural formulae of estradiol, progesterone and
testosterone and their importance. Peptide hormones-oxytocin and insulin – action, uses and side
effects.Sulpha drugs, Antimicrobial, Analgesic-anti-inflammatory, Cardiovascular agent,
Antihistamines, Antilaprosy and Vitamins.
Uric acid: Structure and synthesis of Uric acid, conversion of uric acid to purine and caffeine,
Synthesis of guanine and theobomine.
Course Objectives
- Students will be familiar with important classes of heterocyclic organic compounds, classification <br />between electron rich and electron deficient heterocycles and their reactivities.
- The course would provide the knowledge about the bio-availability, isolation, stereochemistry and <br />synthesis of some important natural products.
- Students will gain theoretical expertise in synthesis, application and biological activity of various <br />important classes of heterocyclic compounds and natural products.
Course Outcomes
)Students will be familiar with important classes of heterocyclic organic compounds, classification <br />between electron rich and electron deficient heterocycles and their reactivities. <br />2) The course would provide the knowledge about the bio-availability, isolation, stereochemistry and <br />synthesis of some important natural products. <br />3)Students will gain theoretical expertise in synthesis, application and biological activity of various <br />important classes of heterocyclic compounds and natural products
Essential Reading
- T. L. Gilchrist, Heterocyclic Chemistry, Pearson Education, 3rd Ed. 2007, , Pearson Education, 3rd Ed. 2007.
- John A. Joule and Keith Mills, , Heterocyclic Chemistry, Wiley-blackwell 4th ed, 2000., Wiley-blackwell 4th ed, 2000
Supplementary Reading
- Alan R. Katritzky and Pozharski, Handbook of Heterocyclic Chemistry Academic Press 2nd Ed. 2000, Academic Press 2nd Ed. 2000.
- K. C. Nicolaou, T. Montagnon, Molecules that changed world, Wiley-VCH, 1st ed., 2008.