Course Details
Subject {L-T-P / C} : BM6536 : Advanced Bioreactor Engineering { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Angana Sarkar
Syllabus
Stoichiometry of biocatalyic processes: mass balancing, electron balancing and degrees of reduction, Modes of bioreactor operation: growth kinetics, batch, fed-batch and continuous operation. Productivity optimization and cost minimization, Bioreactor design: size estimation, single or multiple vessels, impeller and sparger systems. Bioreactor monitoring and control: instrumentation, on-line and off-line analyses, control algorithms, Bioreactor sterilization: cell death kinetics, batch and continuous systems, filter sterilization of gasses and liquids, safe and contained operation, Oxygen transfer: mass transfer theories and correlations, design for oxygen transfer, bubble size, gas hold-up, Mixing and power consumption: power number and impeller design, mixing time and reactor heterogeneity, effect of aeration and broth rheology. Scale-up and scale down process for bioreactor, benefits of process scale down, regime analysis and strategies for scale down experimentation including process. automation, Reactor design equations, reactor selection and operation, Improving bioreactor performance, Special bioreactors.
Course Objectives
- To know about product based bioreactor designing
- To learn the operation of bioreactor for optimum production
Course Outcomes
Bioreactor design characteristics and monitoring and control systems <br />Bioreactor operation and scale-up impacts on cell growth and productivity <br />Application of basic knowledge on bioreactor engineering to industrial practice
Essential Reading
- Doran, P.M, Bioprocess engineering principles, Academic press
- Bao, J., Ye, Q. and Zhong, J.J., Bioreactor Engineering Research and Industrial Applications II, Springer
Supplementary Reading
- J E Bailey and D F Ollis, Biochemical Engineering Fundamentals, Mc Graw& Hills
- M. L. Shuler and F. Kargi, Bioprocess Engineering: Basic Concepts, Prentice Hall of India