Course Details
Subject {L-T-P / C} : BM0005 : Biomaterials and Tissue Engineering { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Devendra Verma
Syllabus
Introduction to biomaterials, Structure-function-properties relationship of biomaterials, Cell-biomaterials interactions, Scaffold Fabrication and Characterization: Preparation of 2D polymer Films Preparation of 3D porous scaffold by Salt Leaching Method Preparation of 3D porous scaffold by Freeze Drying method Preparation of 3D porous scaffold by freeze gelation method, Preparation of nanofibrous scaffold by Electrospinning method Characterization of scaffold: pore size & porosity and mechanical Strength contact angle measurement swelling behavior Culture of MSCs, Cell counting & cell morphology Seeding of MSCs on scaffolds MTT Viability Test Differentiation of MSCs into bone cells in the scaffold Characterization of tissue engineered bone.
Course Objectives
- Learn the fundamental principles of the interactions of biological molecules and cells with biomaterials employed for tissue engineering applications.
- Able to design a Scaffold considering the biodegradability and main issues of biocompatibility including toxicity.
Course Outcomes
-Explain the fundamental aspects of biomaterials and tissue engineering. <br />-Understand the problems, challenges and future directions of the field. <br />-Able to suggest the type of biomaterials for specific tissue regeneration.
Essential Reading
- Peter X. Ma, Biomaterials and Regenerative Medicine, Cambridge University Press , 2014
- Clemens A. van Blitterswijk and Jan De Boer, Tissue Engineering, Academic Press , Second Edition 2015
Supplementary Reading
- B. Palsson, S. Bhatia, Tissue Engineering, Pearson Education India , First edition 2016
- R. P. Lanza, R. Langer and W. L. Chick, Principles of tissue engineering,, Academic press , 4th Edition, 2013