Course Details
Subject {L-T-P / C} : BM0001 : Fundamentals of Mechanobiology { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Dr. Anju R. Babu
Syllabus
Introduction to biomechanics– Force vectors, Coplanar, collinear and concurrent forces, moment and torque, Statics: Analysis of systems in equilibrium, Applications of statistics to Biomechanics, Introduction to dynamics, linear kinematics and kinetics, angular kinematics and kinetics, work-energy methods, Stress and strain, Computational biomechanics, Multiaxial Deformations and stress analysis- Stress transformation, Principle stresses, Failure theories, Torsion, Bending, Mechanobiology of biological tissues- skeletal tissues (bone, articular cartilage, tendons and ligaments), Bone and tissue remodeling, Gait analysis, Cellular cytoskeleton, Intracellular signalling, Cell migration, Durotaxis, Mechanotaxis, Chemotaxis, Mechanics of biomembranes, Molecular Mechanics and Dynamics, Continuum mechanics, Microstructural models, Constitutive laws, electromechanical and physicochemical properties of tissues, Viscoelasticity, Models of Viscoelasticity, Fracture and Fatigue, Experimental measurements of mechanical behaviour Cells and tissues.
Course Objectives
- This course integrates mechanic and biology to understand the functional properties of biological systems during development, physiological condition, and disease state.
Course Outcomes
At the end of the course, the student will be: <br />1.Familiarize with essential methodologies to understand the mechanobiology of tissue adaptation and regeneration <br />2.Understand the structure-function relationships of tissues <br />3. Insight into the importance of mechanics to understand the cell and tissue behavior
Essential Reading
- NihatOzkaya and Margareta Nordin, Fundamentals of biomechanics: Equilibrium, Motion and deformation, 2nd Edi. Springer , 1999
- Y.C Fung, Biomechanics – Mechanical Properties of Living Tissues, Springer , 1993
Supplementary Reading
- Roger Bartlett, Introduction to Sports Biomechanics: Analysing Human Movement Patterns, Taylor and Francis , 2007
- Christopher R. Jacobs, Hayden Huang, Ronald Y. Kwon, Introduction to Cell Mechanics and Mechanobiology, Garland Science , 2012