Course Details
Subject {L-T-P / C} : BM3301 : Bioprocess Instrumentation and Control { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Dr. Ravi Kant Avvari
Syllabus
Module I
Bioprocess – historical background, stages of bioprocessing, bioreactor – types and design considerations, process modelling – 1st/2nd order and higher order, instrumentation and control, principles of measurements and classification of process control instruments, process flow diagram.
Module II
Sensors: gas, level, foam, flow rate, temperature and heat, humidity, density, viscosity and consistency, turbidity, pressure, pH, redox potential and dissolved oxygen. Biosensor using amperometric, potentiometric, thermistor FET, fluorimetric, fiber optics and bioluminescence. Microbial biosensors.
Module III
Chromatography, spectroscopy (electromagnetic, mass and nuclear magnetic resonance). Spectrophotometry (UV/ VIS/ NIR, fluorescence, circular dichroism), light scattering spectroscopy and atomic absorption spectroscopy. Gas analyzers, ion-specific analyzer, continuous flow analyzer (CFA), flow injection analyzer (FIA), and the high performance liquid chromatography (HPLC). Actuators: compressors, pumps, valves (pneumatic, solenoid), positioners - servo motor.
Module IV
Process flow diagram – types, modelling and analysis. Concept of process control – online and offline monitoring, control system modeling – 1st and 2nd order process, P/PI/PID controller, implementation of control loops, digital controllers, examples.
Course Objectives
- To become familiar with various methods of bioprocess control and instrumentation.
- To understand the basic principles of sensors and actuators
- To learn the techniques of spectroscopy in bioprocess engineering
- To design P/PI/PID controllers for controlling the process.
Course Outcomes
At the end of the course the student will be able to: <br />CO1: Explain the use of control and instrumentation in bioprocess engineering. <br />CO2: Describe dynamic behavior of bioprocesses in the bioreactor. <br />CO3: Identify instruments for the measurement of a process parameter. <br />CO4: Explain the basic principles of chromatography and spectroscopy. <br />CO5: Develop the closed loop control system using P/PI/PID controller.
Essential Reading
- John Twork, Alexander M. Yacynych, Sensors in Bioprocess Control, CRC Press , Biotechnology and Bioprocessing Series
- Donald R. Coughanowr, Steven E. LeBlanc, Process Systems Analysis and Control, McGraw Hill
Supplementary Reading
- RS Khandpur, Handbook of analytical instruments, McGraw Hill
- William. Bolton, Instrumentation and Control Systems, Newnes