Course Details
Subject {L-T-P / C} : BM3303 : Biochemical Engineering { 3-1-0 / 4}
Subject Nature : Theory
Coordinator : Prof.(Ms.) Krishna Pramanik
Syllabus
Introduction to Biochemical Engineering, Enzyme Kinetics, Michaelis-Menten kinetics, Briggs-Haldane kinetics, Numerical solutions, Biokinetic parameters, enzyme reactors, Batch, Plug flow, Continuous Stirred Tank Reactor. Inhibition of enzyme reactions, Effects of pH, temperature and shear. Immobilized enzyme system- Industrial importance, techniques and diffusional limitations. Immobilized enzyme reactor. Growth kinetics, Monod’s model, Factors affecting specific growth rate, batch and Plug Flow, Contious stirred tank fermentors, Monod kinetic parameters, multiple fermenter in series, fermenter in cell recycling. Agitation and aeration- importance, correlation for mass transfer coefficient, interfacial area, mechanical agitation, Gas hold-up, power consumption, oxygen absorption rate, bioreactor scale-up.
Course Objectives
- To provide the students to learn the basic engineering principles for carrying out biological reactions
- To analyze the reaction kinetics and reactor systems involved in enzyme-and immobilized enzyme-catalyzed reactions
- To analyze the reaction kinetics and various fermenter systems involved in microbial cell kinetics
- to learn the basic mass transfer concept, the influence of agitation and aeration in a biological reaction, and the scaling up of bioreactor systems.
Course Outcomes
The students will be able.. <br />1.To learn the chemical engineering principles and the role of biochemical engineers to carry out biological processes. <br />2. To learn and analyse the reaction kinetics and reactor systems involved in enzyme catalysed reactions. <br />3. To learn the industrial importance of immobilized enzyme and analyse the reaction kinetics involved in immobilized enzyme reactions. <br />4. To calculate the microbial growth kinetics and evaluate the performance of different bioreactor/fermenter systems. <br />5. To learn the basic mechanism of mass transfer, influence of agitation and aeration in a biological reaction and to scale up the bioreactor systems.
Essential Reading
- D. G. Rao, ., Introduction to Biochemical Engineering,, Tata McHill, , 2005
- James Lee, Biochemical Engineering Fundamentals, ., Prentice- Hall , 2009
Supplementary Reading
- M. L. Shuler and F. Kargi, Bioprocess Engineering Basic concepts., Prentice- Hall
- Doran, P.M, Bioprocess Engineering Principles,.,, Academic Press , 2012