Course Details

Subject {L-T-P / C} : BM6137 : Regenerative Medicine { 3-0-0 / 3}

Subject Nature : Theory

Coordinator : Prof. Indranil Banerjee

Syllabus

Regeneration: An over view, Evolutionary perspective and origin of regeneration, Repair vs Regeneration, Tissue specificity, Types of regeneration (physiological regeneration , reparative regeneration (epimorphic regeneration ) hypertrophy , morphallaxis). Regeneration and aging. Developmental clues in regeneration.
Cells in Regeneration: Stem cell (embryonic stem cell and adult stem cells, cell source, type, properties, signaling, stem cell niche), progenitor cells, dedifferentiated cells, and trans-differentiated cells. Extrinsic factors that influence regeneration. Morphogenesis and re-integrative processes in regeneration.
Practice of regenerative medicine: Therapeutic regeneration of bone marrow, skin, bone, muscle, heart, pancreas and liver. Induced pluripotent stem cell and its application in regenerative medicine. Induced regeneration (growth factor and gene therapy, tissue inductive scaffold based approach, smart therapeutic system). Ethical issues of regenerative medicine.

Course Objectives

Course Outcomes

After completing the course, the student will be able <br /> <br />(i) to differentiate between repair and regeneration and identify the process of regeneration in different species including human by analyzing the course of tissue /organ regrowth. <br />(iii) to design a therapeutic strategy for the regeneration of a given tissue organ <br />(iii) to analyze the outcome of a regenerative process by accounting the contribution of participating cells and other factors. <br />(iv) to compare and appreciate among different strategies used in regenerative medicine.

Essential Reading

Supplementary Reading

Journal and Conferences