Course Details
Subject {L-T-P / C} : BM6434 : Protein Conformational Diseases and Therapy { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Subhankar Paul
Syllabus
Introduction to Protein Architecture, Cooperative Transitions in Protein Molecules, Kinetics of Protein Folding and the Energy Landscape Model, Introduction to Misfolding, Aggregation, and Disease, Thermodynamics of protein folding, misfolding and aggregation Neurodegenerative disorders, Alzheimer’s disease, Parkinson’s disease, Prion disease, polyglutamine diseases, Amyloidosis. Other protein misfolding disorders: Cystic fibrosis, alpha-antitrypsisn deficiency, Fabry disease, cancer Various Experimental Models in diseases. Disease mechanism, Genetic mutation in diseases, Dysfunction of proteasome in diseases. Role of chaperones in various pathogenesis Study of Disordered Proteins and Aggregation, Intrinsically Disordered Proteins Current therapy chemicals drugs, chaperone-based therapy in neurodegeneration, Proteasome inhibitors, Gene therapy etc.
Course Objectives
- Conformational disease, protein quality control system, chaperone, inherited disorders.
- Students will gain familiarity with principles of protein misfolding, and diseases.
- Medical Aspects of disease: Diagnosis and current therapy
Course Outcomes
1. Enable syudents to understand about protein conformation, folding, misfolding and aggregation. <br /> 2. Enable students to understand amyloid process and mechanism. <br /> 3. Students will be able to apply of various therapeutic strategies in amyloid mediated diseases.
Essential Reading
- V.N. Uversky and A. Fink, Protein Misfolding, Aggregation and Conformational Diseases (Protein Reviews), Springer , First edition, 2007
- . H. Smith, C. Simons, and R.D. E. Sewell, Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies (Enzyme Inhibitors), CRC Press , First edition, 2007
Supplementary Reading
- J. Ovádi and F. Orosz, Protein folding and misfolding: neurodegenerative diseases (Focus on Structural Biology), Springer , First edition, 2009
- V.N. Uversky and A. Fink, Protein Misfolding, Aggregation and Conformational Diseases (Protein Reviews), Springer , First edition, 2007