Course Details
Subject {L-T-P / C} : BM6442 : Advanced Cell and Molecular Engineering { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Bibhukalyan Prasad Nayak
Syllabus
Introduction: Eukaryotic vs. Prokaryotic cell and the complexities introduced in eukaryotes at cellular level, Cell Junctions: Types and structure of junctions (Desmosomes, Hemi-desmosomes, Adherens junctions, Tight junctions, Gap junction), molecular organization, technologies to characterize and visualize the cell junctions Cell Adhesion Molecules: classification (CAM, Cadherin, Integrins etc.), molecular structure in details, function Cell surface Receptors: Ion linked Receptors, Enzyme Linked Receptors (serine/Threonine kinases R, Tyrosine kinase R, Guanine cyclase R), Cytokine Receptor superfamily, GPCR Signal Transduction via Surface Receptors (Jak-Stat, R-Smod/Co-Smad, Ras-MAPK, NFkB/JNK, NFkB/MAPK and TOLR pathways, GPCR pathways): Emphasis on GPCR pathways, cAMP Signaling from Receptor to Function Dual Signaling Pathway: Inositol phosphates and protein kinase C, calcium & calmodulin Cross-Talk and Scaffolding proteins, signal amplification & cascade mechanisms Microtubules & Motor Proteins MTs organization,MAPs and motor proteins(kinesin/dynein), IFs, microfilaments, myosins (types, structure, processivity, functionChemotaxis: chemokines, chemokine receptors & the Inflammatory response Receptor-Mediated Endocytosis Vesicle Trafficking: COPs, SNARES Cell Cycle: stages, regulation of cell cycle specific genes.
Course Objectives
- To enable students learn latest findings in cell and molecular biological processes.
- To learn the advanced technologies of wet lab experiments.
Course Outcomes
1. The students would be exposed to the most recent research work in cell and molecular biology and can get a clear picture regarding the potential field to carry out their doctoral research. <br />2. The students get an in depth knowledge concerning the engineering principles of advanced cell and molecular biology techniques.
Essential Reading
- G. Nindl Waite, Applied Cell and Molecular Biology for Engineers, McGraw-Hill
- G. Karp, Cell and Molecular Biology: Concepts and Experiments, Willey
Supplementary Reading
- B. Alberts, Molecular Biology of the Cell, Garland science
- No thanks, No thanks, No thanks