Course Details
Subject {L-T-P / C} : CY3111 : Basic Organic Chemistry { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Gokarneswar Sahoo
Syllabus
Condensation reaction of carbonyl compounds (Aldol condensation, Claisen condensation, Dieckmann condensation, Perkin Reaction, Stobbe Condensation) Aromatic Electrophilic Substitution Reactions (Reimer-Tiemann, Friedel-craft, Vilsmeier formylation reaction) Elimination Reactions (Chugaev, Cope Reaction) Rearrangements involving carbocations (Pinacol-Pinacolone Rearrangement, Wagner-Meerwein Rearrangement, Demjanov Rearrangement) Migration to Electron deficient C-atom (Wolff Rearrangement, Favorski Rearrangement, Fries Rearrangement, Benzil-Benzilic Acid Rearrangement) Migration to Electron deficient N-atom (Hofmann, Beckmann, Curtius, Schmidt, Lossen Rearrangement) Organometallic Reactions (Reformatsky, Grignard, Gilman reaction) Oxidizing reagents: Chromium reagents, manganese reagents, Hypervalent Iodine reagents [Dess-Martin periodinane (DMP), o-iodoxybenzoic acid (IBX)], DMSO based oxidizing reagents (Swern Oxidation), Aluminium alkoxides (Oppenauer Oxidation) Reducing reagents: Heterogeneous catalytic hydrogenation, Homogeneous catalytic hydrogenation (Wilkinson’s Catalyst), Dissolving metal reduction (Clemmesen Reduction Reaction, Birch Reduction) Reduction with hydride-transfer reagents (Aluminium alkoxides Meerwein-Pondroff-Verley reduction, Lithium aluminium hydride, sodium borohydride, DIBAL-H, Borane and derivatives).
Course Objectives
- The student would be exposed to very common and key organic transformations highly used in pharmaceutical industries.
- The student will acquire knowledge about the properties and functioning of common organic reagents.
Course Outcomes
As a minor course, this will provide basic yet enough knowledge in organic chemistry which would be useful in any other branch of science/Engineering. Sometimes synthesis of small organic molecules are necessary for study of its application in other fields, thus this course would be helpful.
Essential Reading
- Ratan Kumar Kar, Name Reactions and Rearrangements in Organic Chemistry, Books and Allied (P) Ltd. , 1st Ed. 2016
- J. Clayden, N. Greeves, and S. Warren, Organic Chemistry, Oxford University , 2nd edition, 2012
Supplementary Reading
- W. Carruthers, I. Coldham, Modern methods of organic synthesis, Cambridge University , 4th edition, 2004
- M. Smith, Organic Synthesis, McGraw Hill , 2nd Ed. 2004