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Current research
Multifunctional mesoporous hollow silica nanocapsules for targeted co-delivery of cisplatin-pemetrexed and MR imaging. Sasmita Mohapatra⃰ and Smruti Ranjan Rout, Department of Chemistry.

M
ultifunctional nanomaterials with combined features of diagnostic and therapeutic applications have been one of the key issues in nanomedicinal research. The main approach for the design of multifunctional theranostic nanoparticles is the simultaneous incorporation of a diagnostic element and
therapeutic agents into a single particle. On the otherhand, combination therapy or simultaneous administration of multiple drugs has become a widely adopted strategy in clinical cancer therapy. For instance, a relatively new drug pemetrexed (Alimta, Eli Lily), when given with cisplatin can reduce tumor size up to 40%, and thus increase the longevity of the patient. In the present work, we have developed hollow mesoporous silica nanoparticles with high surface area which are capable of encapsulating hydrophobic drug pemetrexed and magnetic oxide based T2 contrast agent, where the hydroxyl groups on the exterior surface can be chemically modified to conjugate platinum anticancer drugs, folic acid and a fluorescent molecule RITC. More in Dalton Transactions, 2014, 43 (42), 15841– 15850. Project Supported by BRNS, DAE. (List of Research)

NEW SPONSORED PROJECT
Innovation and Entrepreneurship Development Centre
PI: Prof. Rajeev Kumar Panda
Sponsor: NSTEDB, DST
 
Identification of piRNA associated genomic and epigenom .......
PI: Prof. Bibekanand Mallick
Sponsor: DST
 
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