Course Details
Subject {L-T-P / C} : CY3102 : Bio-organic Chemistry { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof.(Ms.) Sabita Patel
Syllabus
Carbohydrates: Classification, Monosaccharides, erythroabdthreodiasteromers, epimers, cyclic
structures of monosaccarides, mutarotation, reactions of monosaccarides, reducing and nonreducing sugars, chain-shortening and lengthening of sugars, proof of configuration, determination
of ring size, disaccharides and polysaccharides.
Amino acids: Classification and nomenclature, configuration, acid-base properties, isoelectric point,
synthesis and chemical properties of a-amino acids. Peptides: peptide bond, biologically important
peptides (glutathione, oxytocin-important functions). Proteins: Classification (Primary, Secondary,
Tertiary, Quaternary- definition, examples) Forces that stabilize structure of proteins: H-bonds,
Department Of Chemistry
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hydrophobic interaction, electrostatic attraction, Van der Waal's interaction, dipole-dipole
interaction.
Nucleic Acids: Purine and pyrimidine bases of nucleic acids, base pairing via H-bonding, structure of
ribonucleic acid (RNA) and deoxyribonucleic acid (DNA), double helix model of DNA and forces
responsible for holding it. Chemical synthesis of mono and tri nucleosides.Chemical Properties:
Hydrolysis (acid, alkali), enzymatic hydrolysis of DNA. General structure and types of RNA (tRNA,
mRNA, rRNA).
Natural Products: Isolation and structure elucidation of Terpenoids (Citral,Geraniol, Menthol),
alkaloids (Nicotine, atropine).
Course Objectives
- Students will be introduced about bioactive molecules starting from small amino-acids and <br />carbohydrates to complex terpenoids, drugs and vitamins.
- This course offers a detailed study of the above structures, synthetic preparations etc and will <br />enable the students to learn how the reactivity of organic compounds can be used to achieve the <br />ultimate target, i.e. synthesis of the bioactive natural products.
Course Outcomes
This course offers a detailed study of the above structures, synthetic preparations etc and will <br />enable the students to learn how the reactivity of organic compounds can be used to achieve the <br />ultimate target, i.e. synthesis of the bioactive natural products.
Essential Reading
- I. L. Finar, Organic Chemistry, Volume 1, 6th Edition, Pearson Education, 2002., Pearson Education, 2002.
- S. V. Bhat, B.A. Nagaramgagi, M. Srikumar, Chemistry of Natural Product, Alpha Science International Ltd, 2005.
Supplementary Reading
- David J Hart., Organic Synthesis via Examination of selected natural products, .World scientific 2011
- James R Hanson, Natural Products: the secondary metabolites, RSC, 2003.