Course Details
Subject {L-T-P / C} : CY6103 : Introduction to Medicinal Chemistry { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof.(Ms.) Sabita Patel
Syllabus
Introduction to medicinal chemistry, Basic concepts, Lead discovery and lead modification, Drug receptors, Drug-Receptor interaction, Drug action at receptors, Enzymes, Substrate binding at an active site of enzyme, Mechanism of Enzyme catalysis, Enzyme catalysis in drug discovery, Enzyme inhibition and inactivation, Nucleic acids as drug targets, Drugs acting on DNA, Drug Resistance, Drug synergism, Metabolism of drugs, Prodrugs, Drug delivery systems, Drug design and QSAR, , Combinatorial chemistry, Structure-activity relationships, Specific drug families, Anteoplastic agents, Antibiotics, Cardiovascular Drugs, Antifertility agents, Diuretics.
Course Objectives
- The aim of this course is to introduce the basic concepts of medicinal chemistry and drug design.
- To learn brief idea on various classes of therapeutic agents with the emphasis on their synthesis, physico-chemical properties, mechanism of action, metabolism, adverse effects, Structure Activity Relationships (SAR) and therapeutic uses.
Course Outcomes
Students will learn the chemistry behind the development and activity of drugs. Students will have a clear understanding on how drugs interact with biological targets and the role of medicinal chemists and chemistry in drug design.
Essential Reading
- Richard B. Silverman Mark W. Holladay, 1. The Organic Chemistry of Drug Design and Drug Action, Elsevier , 3rd edition, 2015
- G.L. Patrick, 2. An Introduction to Medicinal Chemistry, Oxford University Press , 5th edition, 2013.
Supplementary Reading
- Erland Stevens, 1. Medicinal Chemistry: The Modern Drug Discovery Process, Pearson , 1st Edition, ISBN-10: 0321710487 / ISBN-13: 9780321710482
- S.S. Pandeya and J. R. Dimmock, 2. Introduction to Drug Design, New Age International.