Course Details
Subject {L-T-P / C} : CY5101 : Methods in Organic Synthesis { 3-1-0 / 4}
Subject Nature : Theory
Coordinator : Prof. Gokarneswar Sahoo
Syllabus
C-C bond forming reactions: Main Group Chemistry – Organometallic reagents in Organic synthesis: Principle, preparations, properties and applications of the following in organic synthesis with mechanistic details: Organomagnesium (Grignard reaction), Organozinc (Reformatsky Reaction), Organolithium, Organoaluminium, Organosilicon, Organocerium, Organoborane (Hydroboration of alkenes, Allyl boranes, CBS reaction), Organocadmium, Organomercury, Organotin (Reduction with tri n-Butyltinhydride) compounds. Transition–metal Chemistry: Organotitanium, Organochromium, Organoiron, Organocopper, Organopalladium compounds, Metal carbenes (Fischer Carbene, Schrock carbene and their application). Protecting groups: Protection of alcohols, 1,2-diols, 1,3-diols, thiols, carboxylic acids, carbonyl compounds, amines. Protection of carbon-carbon multiple bonds. Illustration of protection and deprotection in synthesis. The Disconnection Approach: One-group and two-group disconnections, control in carbonyl condensations, Umpolung, radical reactions in synthesis, use of acetylenes, ring annulation strategies. Cross-coupling C-C reactions involving boron, tin, silicon reagents and aryl/alkenyl/alkynyl and alky halides. Metathesis and Grubb’s Catalyst. Organocatalysis: Introduction to organo-catalyzed reactions, Classifications (HOMO, LUMO, SOMO catalysis), Enamine, Iminium, H-bonding catalysis and asymmetric organocatalysis (Michael, aldol, Mannich etc).
Course Objectives
- This course contains organic reactions at an advanced level appropriate for Master's degree to prepare them further for future research in organic and pharmaceutical chemistry.
- The course broadly consists of five topics: C-C Bond Forming Reactions: Main Group Chemistry, Transition–metal Chemistry, Protecting groups, The Disconnection Approach, and Organocatalysis
Course Outcomes
1) This course enables an exposure to the basic fundamentals of organic reactions. <br />2) The students will have a better understanding on various synthetic methodologies employed in organic Synthesis.
Essential Reading
- Stuart Warren, Paul Wyatt, Organic Synthesis: The Disconnection Approach, Wiley , Second Edition
- William Carruthers and Iain Coldham, Modern Methods of Organic Synthesis, Cambridge University Press , Fourth Edition
Supplementary Reading
- Michael B. Smith, Organic Synthesis, McGraw Hill International Editions , Fourth Edition
- V. K. Ahluwalia and R. K. Parashar, Organic Reaction Mechanisms, Narosa Publishing House , Fourth Edition