Course Details
Subject {L-T-P / C} : BM4101 : Bioinformatics { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Prof. Mukesh Kumar Gupta
Syllabus
Scope of bioinformatics and computational biology, Major bioinformatics resources (NCBI, EBI, ExPASy), Sequence and structure databases, Data Mining, Understanding large scale DNA and protein sequencing and arrays, Sequence analysis, biomolecular sequence file formats, scoring matrices (PAM and BLOSUM), sequence alignment, gene prediction, phylogeny, knowledge discovery in biochemical databases, NGS Sequence analysis pipeline, Molecular modelling and simulations.
Course Objectives
- • To provide basis understanding of bioinformatics in biotechnology and medical engineering.
- • To solve bioindustrial problems using modern bioinformatic tools for gene annotation, functional proteomics, molecular phylogeny etc.
- • To train on the development and use of bioinformatic softwares and provide logistics to the development of modern bioinformatic tools for bio-molecular simulations, 3-D protein modelling, computer-aided drug design and molecular docking.
Course Outcomes
• Understand the aim and scope of bioinformatics in biotechnology and medical engineering. <br />• Gain knowledge on bio-algorithms, bio-databases, information retrieval, data mining, file formats, molecular viewer etc. <br />• Analyze and provide solution to bioindustrial problems using modern bioinformatic tools for gene annotation, functional proteomics, molecular phylogeny etc. <br />• Use bioinformatic softwares and provide logistics to the development of modern bioinformatic tools for bio-molecular simulations, 3-D protein modelling, computer-aided drug design and molecular docking.
Essential Reading
- • Pevsner J, . Bioinformatics and Functional Genomics, Wiley-Blackwell, USA , ISBN: 978-81-265-3834-8
- • Lesk AM, Introduction to Bioinformatics, Oxford University Press
Supplementary Reading
- • Bergeron B, Bioinformatics computing, Prentice Hall, USA , ISBN: 0-13-100825-0
- • Xiong J, Essential bioinformatics, Cambridge University Press, USA , ISBN: 978-0521600828.