Course Details
Subject {L-T-P / C} : BM4608 : BioMEMS and Biomicrofluidics { 3-0-0 / 3}
Subject Nature : Theory
Coordinator : Dr. Earu Banoth
Syllabus
Module-I: Introduction to MEMS and BioMEMS, Silicon microfabrication: materials and methods Microfabrication using soft substrate: materials and methods, biomedical application of MEMS devices.
Module-II: Introduction to microfabrication and types of Microfabrication techniques: Photolithography, E-Beam Lithography, X-ray Lithography, Soft lithography, etc.
Module-III: Basic principles in microfluidics, design principles for microfluidic devices, device fabrication procedures, (such as optical lithography and soft lithography), components of microfluidic devices utility of microfluidic devices in various biological, chemical, and optical sensing applications, optofluidics, Inertial-microfluidics, droplet-microfluidics, microfluidics based-flow cytometry.
Module-IV: Characteristics of microflow, Flow actuation: electrokinetic flow, pressure driven flow, surface energy driven flow, centrifugal microflow. Concept of bio-microfluidics, Design and function of H-filter and T-sensor, Peclet number.
Module-V: Concept of ‘Lab on a chip’, Components of lab-on-a chip: micropump, microvalve, micromixer, microsensor, lenses, heaters, sensors, etc. Field flow fractionation (FFF), Microfluidic PCR, Microfluidic cell sorter, Lab-on-chip array for biomolecules, Minimally invasive biomedical microdevices, and Microfluidics Future prospects.
Course Objectives
- To aware the students about the fundamental principles of microsystems.
- To provide the concepts essential for the designing of lab-on -a chip and Point -of- care devices for biomedical application.
- Hands on experience of fabricating simple microfluidic device
- Hands on experience of in house microfabrication (Photolithography).
Course Outcomes
After completing the course, the student will be able <br />1. To understand the design of MEMS, BioMEMS, and microfluidics-based analytical platforms per the requirement. <br />2. Ability to identify basic requirements for a design application related to microfabrication and its techniques for biomedical systems. <br />3. To develop the skill to realize, build, and get hands-on experience fabricating simple microfluidic devices. <br />4. To analyze, compare, and appreciate the performance and merit of different lab-on -a chip concepts, designs, and modes of work. <br />5. To analyze, compare and appreciate the performance and merit of different and point-of-care devices' concepts, importance, design, and work mode.
Essential Reading
- E. Meng, Biomedical Microsystems, CRC Press, 2010 , 1st Ed. ISBN-13: 978-1420051223,
- P. Tabeling, S .Chen, Introduction to microfluidics, Oxford University Press, 2010 , 1st Ed. ISBN-13: 978-0199588169
Supplementary Reading
- Suman Chakraborty, Microfluidics and Microfabrication, Springer, 2014 , ISBN-10:9781489984609
- Francesco Piraino and Šeila Selimovic, Diagnostic Devices with Microfluidics, CRC Press 1 edition, 2017 , ISBN-10: 1498772935