BIOGRAPHY
Sujit Kumar Bhutia is currently working as a Professor at the Department of Life Science, National Institute of Technology in Rourkela, India. He received his doctorate in cell biology and cancer from the Indian Institute of Technology, Kharagpur, India in 2009, and subsequently pursued post-doctoral research on autophagy and cancer at Virginia Commonwealth University, USA. Dr. Bhutia is studying the mechanistic aspect of autophagy and establishing its role in cancer to modulate apoptosis for better cancer therapeutics. He is also working on autophagy-dependent cell death, cell death type-II and deciphering the distinct molecular pattern from autophagy. His laboratory is also studying the crosstalk between autophagy and apoptosis and identifying the key molecules in switching and regulating the phenomena among them. Moreover, another focus is on potent mitophagy-inducing molecules from natural sources to diminish cell death and cytotoxic effects.
EXPERTISE INFORMATION
Research Group
- Cell and Developmental Biology
Areas of Interest
- Cancer and cell death
Sujit Kumar Bhutia Professor & PIC (Lawn and Garden)
Life Science
sujitb@nitrkl.ac.in
0661 - 246 2686
159
PUBLICATIONS19
SPONSORED PROJECTS22
DOCTORAL STUDENTS3
CONTINUING EDUCATIONPERSONAL INFORMATION
Sujit Kumar Bhutia
Professor
Life Science
Room Number: MN-339
Department of Life Science, National Institute of Technology Rourkela, Sundargarh, Odisha, India - 769008
2009
Ph.D.
Cancer and cell deathIndian Institute of Technology Kharagpur
Teaching Experience
- Cell Biology, National Institute of Technology Rourkela, 06 Aug 2008 - Present
Post Doctoral Research Experience
- Autophagy and Cancer, Virginia Commonwealth University, 14 Oct 2008 - 12 Oct 2010
Identification and molecular characterization of autophagy inducing chemo preventive molecules from marine microorganisms to target oral squamous cell carcinoma. DST,Odisha
- Principal Investigator
- 36
- Running Sponsored
Autophagic degradation of PAX9 to maintain stemness in oral cancer stem cells DBT
- Principal Investigator
- 36
- Running Sponsored
To delineate the survival strategy of mycobacteria through antigenic determinants by inhibiting autophagy via miRNA and its significance in host directed therapy. DBT
- Co-Investigator
- 36
- Running Sponsored
Screening and identification of canonical mitophagy inducing phytochemicals from Bacopamonnieri to target NLRP3 inflammasome activation for oral cancer therapeutics. DBT
- Principal Investigator
- 36
- Running Sponsored
Analysis of role of MTP18-dependent mitophagy in oral carcinogenesis and its targeting to activate m. BRNS
- Principal Investigator
- 36
- Running Sponsored
Deciphering MTP18 as an inner membrane mitophagy receptor in clearance of damaged mitochondria subdomains and its relevance in mitoptosis. Science & Engineering Research Board(SERB)
- Principal Investigator
- 36
- Running Sponsored
Analysis of Pax9 methylation in oral carcinogenesis and its reactivation leading to lethal autophagy for potential cancer therapeutics. ICMR
- Principal Investigator
- 36
- Completed Sponsored
Stress induced clearance of dysfunctional Mitochondria through Puma dependent Mitophagy. CSIR
- Principal Investigator
- 60
- Completed Sponsored
Genomewide profiling of PIWI0interacting RNAs (piRNAs) by Next-Generation Sequencing and investigating their role in Oral Squamous Cell Carcinoma. DBT, Govt Of India
- Co-Investigator
- 36
- Completed Sponsored
Deciphering role of autophagy in stemness and therapy resistance in oral cancer stem cells DBT
- Principal Investigator
- 36
- Completed Sponsored
Inspire and fist division dept of science & technology DST-FIST
- Principal Investigator
- 60
- Completed Sponsored
Stonin-2 regulated Beclin-1 dependent autophagy and autophagic lysosome reformation Science & Engineering Research Board(SERB)
- Principal Investigator
- 36
- Completed Sponsored
Protective autophagy by secretory clusterin associated with cell survival and chemoresistance in oral cancer BRNS
- Principal Investigator
- 36
- Completed Sponsored
Molecular Profiling of apoptotic pathway in cancer stem cells of oral squamous cell carcinoma and its modulating by plant lectins DST,ODISHA
- Principal Investigator
- 36
- Completed Sponsored
Autophagy induced by cellular Stress Switches to apoptosis DBT
- Principal Investigator
- 36
- Completed Sponsored
DNA DAMAGE-INDUCED P73-MEDIATED APOPTOSIS WITH ABRUS AGGLUTININ IN ORAL CANCER CSIR
- Principal Investigator
- 36
- Completed Sponsored
Deciphering role of cancer stem cells to therapy resistance in oral cancer SERB
- Principal Investigator
- 36
- Completed Sponsored
Autophagic cell death induction with Abrus agglutinin DBT
- Principal Investigator
- 36
- Completed Sponsored
Development of functionalized ferrite nanoparticles for targeted Tumor Therapy. DBT
- Co-Investigator
- 36
- Completed Sponsored
Total Publications: 159
S. Mukhopadhyay, P. K. Panda, N. Sinha, D. N. Das, and S. K. Bhutia,"Autophagy and apoptosis: where do they meet?", Apoptosis, vol.19, no.4, pp.555-566, Kluwer Academic Publishers, April 2014, 10.1007/s10495-014-0967-2 Article
S. Mukhopadhyay, D. Das, P. Panda, N. Sinha, P. Naik, A. Bissoyi, K. Pramanik, and S. K. Bhutia,"Autophagy protein Ulk1 promotes mitochondrial apoptosis through reactive oxygen species", Free Radical Biology and Medicine, vol.89, pp.311-321, Elsevier, December 2015, 10.1016/j.freeradbiomed.2015.07.159 Article
S. Mukhopadhyay, I. Schlaepfer, B. Bergman, P. K. Panda, P. P. Praharaj, P. P. Naik, R. Agarwal, and S. K. Bhutia,"ATG14 facilitated lipophagy in cancer cells induce ER stress mediated mitoptosis through a ROS dependent pathway", Free Radical Biology and Medicine, vol.104, pp.199–213, Elsevier, March 2017, 10.1016/j.freeradbiomed.2017.01.007 Article
S. Mukhopadhyay, P. P. Naik, P. K. Panda, N. Sinha, D. N. Das, and S. K. Bhutia,"Serum starvation induces anti-apoptotic cIAP1 to promote mitophagy through ubiquitination", Biochemical and Biophysical Research Communications, vol.479, no.4, pp.940–946, Elsevier, October 2016, 10.1016/j.bbrc.2016.09.143 Article
P. K. Panda, B. Behera, B. R. Meher, D. N. Das, S. Mukhopadhyay, N. Sinha, P. P. Naik, B. Roy, J. Das, S. Paul, T. Maiti, R. Agarwal, and S. K. Bhutia,"Abrus Agglutinin, a type II ribosome inactivating protein inhibits Akt/PH domain to induce endoplasmic reticulum stress mediated autophagy-dependent cell death", Molecular Carcinogenesis, vol.56, no.2, pp.389–401, Wiley, February 2017, 10.1002/mc.22502 Article
Techniques to Understand Autophagic Processes in Mammalian Systems (TUAPMS) Life Science (Workshop)
- Coordinator
- 26 Feb 2020 - 01 Mar 2020
- Brochure
Workshop on Technologies on molecular Analysis of cell and cellular Dynamics (TMCCD) Life Science (Workshop)
- Coordinator
- 19 Nov 2015 - 21 Nov 2015
- Brochure
2nd International Conference on Frontiers in Biological Sciences (InCoFIBS-2015) Life Science (Conference)
- Coordinator
- 22 Jan 2015 - 24 Jan 2015
- Brochure
- EA1270 : Value Education and Ethics {Theory}
- LS100 : Biology {Theory}
- LS1001 : Biology {Theory}
- LS206 : Cell and Molecular Biology {Theory}
- LS311 : Cell and Cellular Techniques {Theory}
- LS403 : Cell Biology {Theory}
- LS405 : Cell Biology {Theory}
- LS406 : Fundamentals of cell biology {Theory}
- LS4407 : Cell Biology {Theory}
- LS508 : Genomics and Proteomics {Theory}
- LS511 : Genetics {Theory}
- LS513 : Enzymology and Metabolism {Theory}
- LS5304 : Genomics and Proteomics {Theory}
- LS552 : Cell-cell Signaling {Theory}
- LS581 : Cancer biology {Theory}
- LS6004 : Cell Signalling {Theory}
- LS604 : Cell Signalling {Theory}
- LS276 : Cell and Molecular Biology laboratory {Practical}
- LS4491 : Cell Biology Laboratory {Practical}
- LS473 : Cell biology Laboratory {Practical}
- LS475 : Immunology Laboratory {Practical}
- LS574 : Computational Genomics and Proteomics Laboratory {Practical}
Ph.D. Students [21]
Elucidating Mechanisms of Benzo[a]pyrene Mediated Apoptotic and Autophagic Cell Death and its Prevention with Phytotherapeutics
Durgesh Nandini DasEnrolled: Jan 2011Graduated : 2014Supervisor
Unraveling The Intricate Molecular Mechanism Between Apoptosis and Autophagy During Cellular Stress
Subhadip MukhopadhyayEnrolled: Jul 2011Graduated : 2016Supervisor
Investigation of the Epigenetic Regulators and Signaling Pathways influencing Pluripotency Inducing Transcription Factors mediated Tumorigenesis
Swayamsiddha KarEnrolled: Jul 2011Graduated : 2016Co-Supervisor
Mechanism of Tumor Inhibitory Potential of Abrus Agglutinin in Oral Squamous Cell Carcinoma
Niharika SinhaEnrolled: Jul 2011Graduated : 2016Supervisor
Autophagy Dependent Cell Death, Senescence and Differentiation by Abrus Agglutinin in Cancer Therapeutics
Prashanta Kumar PandaEnrolled: Sep 2011Graduated : 2016Supervisor
Protective Autophagy in Inducing Stemness and Therapeutic Resistance in Oral Squamous Cell Carcinoma
Prajna Paramita NaikEnrolled: Jul 2013Graduated : 2018Supervisor
Deciphering the Epigenetic Mechanism of Gene Regulation and Evaluation of Medicinal Plant Products in Modulation of Chromatin Modifications in Cancer
Nibedita PradhanEnrolled: Nov 2012Graduated : 2019Co-Supervisor
Deciphering the Role of MTP18 in Mitophagy and its Targeting for Apoptosis Induction in Oral Squamous Cell Carcinoma
Debasna Pritimanjari PanigrahiEnrolled: Jul 2016Graduated : 2021Supervisor
Defining the Role of Clusterin in Autophagy-related Signaling to Control Stemness and Survival Response in Oral Squamous Cell Carcinoma
Prakash Priyadarshi PraharajEnrolled: Jul 2015Graduated : 2022Supervisor
Unravelling the Molecular Connection between PAX9 and Autophagy to Regulate Oral Carcinogenesis
Chandra Sekhar BholEnrolled: Jul 2016Graduated : 2022Supervisor
Deciphering the Role of Stonin 2 in Autophagy and Autophagic Lysosome Reformation to Control Cell Survival in Oral Squamous Cell Carcinoma
Kewal Kumar MahapatraEnrolled: Jul 2017Graduated : 2022Supervisor
Understanding the Role of Sirtuin1-Activating Compounds in Autophagy and Associated Signalling to Induce Cell Death in Oral Cancer
Srimanta PatraEnrolled: Jul 2018Graduated : 2023Supervisor
Investigating the Mechanistic Role of PPA2 in Mitochondrial Fission and its Modulation for Oral Cancer Therapeutics
Soumya Ranjan MishraEnrolled: Jul 2018Graduated : 2023Supervisor
Cancer and cell death
Bishnu Prasad BeheraEnrolled: Jul 2019ContinuingSupervisor
Cancer Cell death and Autophagy
Amruta SinghEnrolled: Aug 2020ContinuingSupervisor
AUTOPHAGY AND CANCER
Rakesh Kumar KarEnrolled: Jul 2022ContinuingSupervisor
Cancer Biology and Autophagy
Priyadarshini MishraEnrolled: Jul 2022ContinuingSupervisor
Cancer Biology
Sushmita PatraEnrolled: Jul 2023ContinuingSupervisor
Cancer biology-Autophagy
Prakash Kumar SenapatiEnrolled: Jul 2023ContinuingSupervisor
MICROBIOLOGY
Poojarani PandaEnrolled: Aug 2023ContinuingCo-Supervisor
Autophagy and Cancer Biology
Pratyasha MahadaniEnrolled: Aug 2023ContinuingSupervisor
Executive Ph.D. Students [1]
Cancer and Stem Cell biology
Manisha DashEnrolled: Aug 2023ContinuingCo-Supervisor
Awards And Honours
- Odisha Bigyan Academy Young Scientist Award in Life Sciences 2015, 2017
- ICMR International Fellowship for Young Indian Biomedical Scientist 2015-16, 2015
- BD Biosciences winner for the research grant program 2013, 2013
Memberships / Fellowships
- Odisha Bigyan Academy, 2012
- Indian Association of Cancer Research, 2008
- American Association of Cancer Research, 2008