Syllabus

Module 1: Substitution Reactions at sp3 Carbons: Types (SN1, SN2, SNi), neighbouring group participation, factors affecting SN reaction, Competition between SN1 and SN2 reactions, Substitution reactions of alcohols, alkyl halides, reactions with epoxides. [6 classes]
Module 2: Addition to C=O: Addition of Carbon, Hydrogen, oxygen, sulphur and Nitrogen nucleophiles to Carbonyl Compounds, Wittig reaction, Schiff’s base-hydrazone, oxime, Cannizzarro’s reaction, acetal Synthesis. [6 classes]
Module 3: a, ß-unsaturated carbonyl compounds-preparation and properties, Michael addition, 1,2 Vs 1,4- addition reaction. [4 classes]
Module 4: Acidity of a-hydrogen:Keto-enoltautomerism, alkylation, acylation, halogenation, Aldol condensation, Robbinson annulation, Perkin’s reaction, Claisen condensation, Dieckmann condensation Reaction, Stobbe Condensation Reaction, Moritas-Baylis-Hilmann reaction, BamfordSteven, Shapiro reaction, base catalyzed halogenations reaction of ketones Iodoform reaction [9 classes]
Module 5: Active methylene compounds and their reactions, Malonic ester, acetoacetic ester. Carboxylic acid and its derivatives (esters, anhydrides, acid halides, amides): Relative reactivities, Nucleophilic acyl substitution reactions, Synthesis and reactions [8 classes]

To define and employ the concept of nucleophile, electrophile, movement of curly arrows

To make correct structural representation of organic molecules and understand the directions organic reactions

To write transformation mechanism of alkyl halides, alcohols, carbonyl compounds

To understand the structure and reactivity relationship

1. Students must be acquainted with organic terminologies
2. Students will be able to transit from memorization to understanding by programmed exposure to integrated problems
3. Student should be able to design the synthesis of small molecules following a multi-step synthetic planning
4. Understand the role of organic chemistry in pharmaceuticals
5. Design the synthesis of organic compounds using enolates

P.Y. Bruice, Organic Chemistry, Pearson Education , 3rd Ed. 2009

T. W. Graham Solomons, Craig B. Fryhle, Scott A. Snyder, Organic Chemistry, Wiley student Edition , 12th Ed. 2016

T. L. Gilchrist, Heterocyclic Chemistry, Pearson Education , 3rd Ed. 2007

J. Clayden, N. Greeves, and S. warren, Organic Chemistry: Second Edition, oxford press , 2014