Syllabus

Introduction to medicinal chemistry: concepts, Biomolecules as drug targets, Proteins and enzymes, Drug receptors, Genetic components as targets, working principle, transport and metabolism of drugs, Prodrugs and drug delivery systems, Drug design and QSAR, Drug discovery and development, Combinatorial chemistry, Structure-activity relationships, Specific drug families, Anteoplastic agents: Cancer chemotherapy, role of alkylating agents and antimetabolites in treatment of cancer, anti-metabolites, carcinolytic antibiotics, mitotic inhibitors, Antibiotics: Constitution and synthesis of penicillins, chloramphenicol, tetracyclic and streptomycine Antimalerials: Synthesis and properties of 8-amino-quinolone derivatives- pamaquine, primapune, pentaquinr, isopentaquine, 4-aminoquinolone derivatives-santoquine, camaquine, acridine derivatives-mepracrine, azacrin, Cardiovascular Drugs: Antihypertensive and hypotensive drugs, antiarrhythmic agents, vasopressor drug direct acting arteriolar dilators. Biological action of methyldopa, propranolol hydrochloride, amyl nitrate, sorbitrate, verapamil, Atenolol. Antihistaminic agents: Ethylene diamine derivatives, amino alkyl ether analogues, cyclic basic chain analogues. Antifertility agents: General antifertility agents. Diuretics: Mercurial diuretic, Non mercurial diuretics (Thiazides, carbonic-anhydrase inhibitors, xanthine derivatives, pyrimidine diuretics and osmotic diuretics.

The course aims to familiarize students with the fundamental concepts of drug discovery and development.

It intends to train students on various aspects of new drug discovery/development, drug screening, target identification, lead discovery, optimization and the molecular basis of drug design and drug action.

The course intends to educate the students about the "Chemistry behind drugs' and their interaction and influence with biological target".

The course would prepare students to make a career in Pharmaceutical Chemistry.

CO1: Students will gain fundamental knowledge on the principles of drug discovery, from target identification to clinical trials, including various screening techniques, lead optimization, and the role of medicinal chemistry in the drug development process.
CO2: Students will be able to develop a strong understanding of how molecular structure influences biological activity, enabling the design and optimization of drug candidates.
CO3: Students will gain in-depth understanding on drug action, metabolism, and toxicity, including pharmacokinetic and pharmacodynamic principles, the biological targets of drugs and the mechanisms of drug action.
CO4: Students will learn different drug delivery strategies and technologies, including nanoparticles, liposomes, and targeted drug delivery systems.
CO5: Students will learn about some specific families of drug, and the chemistry behind their drug action.

G. L. Patrick, An Introduction to Medicinal Chemistry, Oxford University Press , 2013

S.N. Pandeya and J. R. Dimmock, Introduction to Drug Design, New Age International , 2006

Richard B. Silverman and Mark W. Holladay, The Organic Chemistry of Drug Design and Drug Action, Academic Press , Third Edition

Charles O. Wilson, Ole Gisvold, Robert F. Doerge, Textbook of Organic Medicinal and Pharmaceutical Chemistry, Wiley , 1977

Book Review: Textbook of Organic Medicinal and Pharmaceutical Chemistry, Edited by Charles O. Wilson, Ole Gisvold, Robert F. Doerge. https://doi.org/10.1002/jps.2600661052