Syllabus

Module 1: Basic Modelling Principles (8 Contact Hours)
Introduction , definition of modelling and simulation, different types of models, Mass transfer: liquid - liquid, liquid - gas, liquid - solid mass transfer, Stoichiometry

Module 2: Mathematical Models for Biochemical Engineering Systems (10 Contact Hours)
Batch Reactor, CSTR, Fed Batch reactor, Batch Distillation, Isothermal with cooling/heating jacket or coil

Module 3: Modelling of Bioprocesses (6 Contact Hours)
Modelling approaches for Biological Systems Growth Kinetic Models- Structured and unstructured, Compartmental models, deterministic and stochastic approaches, death kinetic models.

Module 4: Numerical Methods and Analysis(5 contact Hours):
Rungge Kutta and Newton Raphson, Stability Analysis, basic data analysis-curve fitting, sensitivity analysis.

Module 5: Case Studies (7 Contact Hours)
Model for: lactic acid fermentation, antibiotic production, ethanol fermentation, activated sludge processes, Anaerobic digestion

Students will be able to develop mathematical models of bioprocesses using mass and heat conservation principles

The students will be able to identify system boundaries and relate the governing variables through a methodological approach.

The students will be able to integrate a differential algebraic system for bioprocess using MATLAB.

Acquire proficiency in recruiting numerical methods for solving models based on difference equations for a particular use case

1. Students would be able to gain understanding of different types of models and methodology generally recruited for bioprocess engineering.
2. The students will be able to develop mathematical models for various bioprocesses with the help of first principles.
3. Students will be able to identify and define a system, state variables and processes of a given bioprocess.
4. The students will be able to understand the principles of solving difference equation based mathematical models.
5. Students will be able to simulate a bioprocess on MATLAB.

J.E. Bailey and D.F. Ollis, Biochemical Engg Fundamentals, McGraw Hill

Michael Shuler and Fikret Kargi, Bioprocess Engineering: Basic Concepts, Prentice Hall

William Luyben, Process Modelling, Simulation and Control for Chemical Engineers, McGraw Hill

Michael Shuler and Fikret Kargi, Bioprocess Engineering: Basic Concepts, Prentice Hall