Syllabus

Module 1- Introduction to protein folding (8 hours)
Introduction to Protein Architecture, Cooperative Transitions in Protein Molecules, Kinetics of Protein Folding and the Energy Landscape Model

Module 2- Protein misfolding, aggregation and related diseases (7 hours)
Introduction to Misfolding, Aggregation, and Disease, Thermodynamics of protein folding, misfolding and aggregation Neurodegenerative disorders, Alzheimer’s disease, Parkinson’s disease, Prion disease, polyglutamine diseases, Amyloidosis. Other protein misfolding disorders: Cystic fibrosis, alpha-antitrypsisn deficiency, Fabry disease, cancer Various Experimental Models in diseases.

Module 3- Disease mechanisms (8 hours)
Disease mechanism, Genetic mutation in diseases, Dysfunction of proteasome in diseases. Role of chaperones in various pathogenesis Study of Disordered Proteins and Aggregation, Intrinsically Disordered Proteins

Module 4- Therapeutic strategies (7 hours)
Current therapy chemicals drugs, chaperone-based therapy in neurodegeneration, Proteasome inhibitors, Gene therapy etc.

Conformational disease, protein quality control system, chaperone, inherited disorders.

Students will gain familiarity with principles of protein misfolding, and diseases.

Medical Aspects of disease: Diagnosis and current therapy

1. Enable syudents to understand about protein conformation, folding, misfolding and aggregation.
2. Enable students to understand amyloid process and mechanism.
3. Students will be able to apply of various therapeutic strategies in amyloid mediated diseases.

V.N. Uversky and A. Fink, Protein Misfolding, Aggregation and Conformational Diseases (Protein Reviews), Springer , First edition, 2007

. H. Smith, C. Simons, and R.D. E. Sewell, Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies (Enzyme Inhibitors), CRC Press , First edition, 2007

J. Ovádi and F. Orosz, Protein folding and misfolding: neurodegenerative diseases (Focus on Structural Biology), Springer , First edition, 2009

V.N. Uversky and A. Fink, Protein Misfolding, Aggregation and Conformational Diseases (Protein Reviews), Springer , First edition, 2007