Syllabus

Module 1 (Introduction) (6 hours)
General design information
Thermodynamics and stoichiometry for bioreactor design
Process calculations
Module 2 (Design of bioreactors) (10 hours)
Stirred tank bioreactors (Batch, continuous)
Airlift and bubble column reactors
Packed bed reactors
Fluidized bed reactors
Trickle bed reactors
Reactors for animal cell and plant cell cultivation
Membrane bioreactors
Scale-up studies
Module 3 (Design of downstream processing units) (10 hours)
Design of heat exchangers
Design of distillation columns and flash columns
Design of filtration units and drying units
Design of chromatography columns
Module 4 (Flow-sheet preparation and economic analysis) (10 hours)
Process flow diagram
Process & Instrumentation diagram for designing process control
Derivation of Mass & Energy flow information
Pinch analysis for heat exchanger design
Case studies of bio-refineries
Hazard and operability study
Calculation of CAPEX and OPEX
Cash flow analysis for determination of economic parameters

To learn details of bioreactor design

To have an idea of designing downstream processing units

To learn the intricacies of process flow sheeting for designing biorefineries

To perform techno-economic feasibility analysis of biorefineries

1. Gain understanding of the process flow diagram and process and instrumentation diagrams used in large-scale biorefineries.
2. Grasp the complexities involved in designing bioreactors
3. Acquire a design-oriented understanding of the downstream processes employed in bio-refineries.
4. Comprehend the specifics of process control within bio-refineries.
5. Obtain comprehension of the steps involved in commercializing a bio-based product from laboratory to commercial scale.

P. M. Doran, Bioprocess Engineering principles, Academic press , Second edition

Peters, Timmerhaus and West, Plant Design and Economics for Chemical Engineers, McGraw-Hill , Fifth Edition

B. K. Lydersen, N.A. D'Elia, and K. L. Nelson,, Bioprocess Engineering, Wiley- Interscience

M. L Shular and F. Kargi,, Bioprocess Engineering- Basic concepts, Prentice Hall,