Syllabus

Module 1: Introduction to Tissue Engineering and Biomaterials for Tissue Engineering (8 hours)
o Basics of Tissue Engineering, triad of tissue engineering
o Structure of polymers, Structure and biodegradation mechanism biodegradable polymers, Biopolymers, Synthetic biodegrdable polymers

Module 2: Cell Biology in Tissue Engineering (6 hours)
o Cell Adhesion and Cell Migration: Mechanisms of cell adhesion, Cell migration processes in tissue regeneration
o Extracellular Matrix (ECM): Structure and function of ECM, Role of ECM in cell signaling and tissue repair
o Cell Aggregates: Formation and significance of cell aggregates, Applications in tissue engineering

Module 3: Scaffold Design and Fabrication (6 hours)
o Designing Scaffolds: Material selection for scaffolds, Mechanical and biological considerations
o Fabrication Techniques: 3D printing, bioprinting, 4D bioprinting, electrospinning, and other scaffold fabrication methods, Sterilization and functionalization of scaffolds
o Cell-Material Interactions: Biocompatibility and biomimicry, Cellular responses to scaffolds, effects of structural properties of scaffolds on cellular response

Module 4: Growth Factors and Delivery Systems (4 hours)
o Role of Growth Factors in Tissue Genesis: Key growth factors, Their role in angiogenesis, osteogenesis, and wound healing
o Delivery Systems for Growth Factors: Controlled release systems, Nano-carriers and hydrogel-based delivery mechanisms

Module 5: Bioreactors, Tissue Production and Regulatory process (6 hours)
o Types of Bioreactors: Static, dynamic, and perfusion bioreactors, Applications in tissue engineering
o Design and Production of Functional Tissue Units: Engineering strategies for functional tissues (e.g., skin, cartilage, bone), Challenges in scaling up tissue production
o Regulatory and Ethical Considerations: Regulatory pathways for tissue-engineered products, Ethical considerations in stem cell and tissue engineering research

Develop advanced knowledge of biomaterials for tissue engineering, their structure and mode of degradation.

Gain knowledge of scaffold design principles, various fabrication techniques, and scaffold-cell interactions and learn how to incorporate growth factors into scaffold systems to enhance tissue formation.

Analyze the design and function of bioreactors used for tissue growth, the development of functional tissue units, and explore clinical applications.

1. Explain the principles of tissue engineering, Ddescribe the structure, biodegradation mechanisms, and biocompatibility of synthetic and natural biodegradable polymers used in scaffold fabrication.
2. Assess the role of extracellular matrix (ECM), cell adhesion, migration, and aggregation in tissue regeneration and engineered tissue formation.
3. Compare different scaffold fabrication techniques and apply different approaches of design and fabrication scaffold.
4. Design and assess different controlled release systems for growth factor delivery.
5. Demonstrate knowledge of bioreactor systems for tissue maturation, functional tissue engineering approaches, and ethical and regulatory frameworks governing tissue-engineered products.

Clemens A. van Blitterswijk and Jan De Boer, Tissue Engineering, Academic Press , Second Edition 2015

B. Palsson, S. Bhatia, Tissue Engineering, Pearson Education India , First edition 2016

R. P. Lanza, R. Langer and W. L. Chick, Principles of tissue engineering, Academic press , 4th Edition, 2013

Peter X. Ma, Biomaterials and Regenerative Medicine, Cambridge University Press , 2014